1 article(s) from Garbe, Daniel
CotB1 synthesizes geranylgeranyl diphosphate (GGDP) 3 from the substrates dimethylallyl diphosphate...
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The bacterial diterpene synthase CotB2wt·Mg2+3·F-Dola in the closed, active conformation (PDB-ID 6G...
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Conformational changes of CotB2 upon ligand binding. Superposition of CotB2’s open (teal), pre-cata...
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View into the active site of CotB2wt·Mg2+3·F-Dola  superimposed with CotB2wt·Mg2+B·GGSDP . (A) The ...
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View into the active site of CotB2wt·Mg2+3·F-Dola . Identical view as in Figure 4. (A) The bound F-Dola rea...
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The WXXXXXRY motif in protein sequences of diterpene TPS from different bacteria. Highlighted is th...
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Overview of the altered product portfolio as a result of introduced point mutations in the active s...
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Catalytic mechanism of CotB2, derived from isotope labeling experiments [34,35], density functional theory...
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(A) The inner surface of the active site is shown in gray. The bound F-Dola reaction intermediate i...
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Variants of CotB2 open the route to a novel product portfolio with altered cyclic carbon skeletons,...
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Beilstein J. Org. Chem. 2019, 15, 2355–2368, doi:10.3762/bjoc.15.228
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