1 article(s) from Hemmerling, Franziska
Schematic description of the cyclisation reaction catalysed by TE domains. In most cases, the nucle...
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Mechanisms for the formation of oxygen heterocycles. The degree of substitution can differ from tha...
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Pyran-ring formation in pederin (24) biosynthesis. Incubation of recombinant PedPS7 with substrate ...
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The domain AmbDH3 from ambruticin biosynthesis catalyses the dehydration of 25 and subsequent cycli...
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SalBIII catalyses dehydration of 29 and subsequent cyclisation to tetrahydropyran 30 .
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All pyranonaphtoquinones contain either the naphtha[2,3-c]pyran-5,10-dione (32) or the regioisomeri...
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Pyran-ring formation in actinorhodin (34) biosynthesis. DNPA: 4-dihydro-9-hydroxy-1-methyl-10-oxo-3H...
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Pyran formation in granaticin (36) biosynthesis. DNPA: 4-dihydro-9-hydroxy-1-methyl-10-oxo-3H-napht...
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Pyran formation in alnumycin (37) biosynthesis. Adapted from .
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Biosynthesis of pseudomonic acid A (61). The pyran ring is initially formed in 57 after dehydrogena...
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Epoxidation–cyclisation leads to the formation of the tetrahydropyran ring in the western part of t...
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a) Nonactin (70) is formed from heterodimers of (−)(+)-dimeric nonactic acid and (+)(−)-dimeric non...
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Pamamycins (73) are macrodiolide antibiotics containing three tetrahydrofuran moieties, which are a...
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A PS domain homolog in oocydin A (76) biosynthesis is proposed to catalyse furan formation via an o...
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Mechanism of oxidation–furan cyclisation by AurH, which converts (+)-deoxyaureothin (77) into (+)-a...
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Leupyrrin A2 (80) and the proposed biosynthesis of its furylidene moiety [69,70].
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Asperfuranone (93) biosynthesis, adapted from .
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The four major aflatoxins produced by Aspergilli are the types B1, B2, G1 and G2 (94–97). In the di...
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Overview on aflatoxin B1 (94) biosynthesis. HOMST = 11-hydroxy-O-methylsterigmatocystin [78,79,82-106].
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A zipper mechanism leads to the formation of oxygen heterocycles in monensin biosynthesis [109-111].
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Formation of the 2,6-dioxabicyclo[3.2.1]octane (DBO) ring system in aurovertin B (118) biosynthesis ...
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Structures of the epoxide-containing polyketides epothilone A (119) and oleandomycin (120) [123-125].
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Structures of phoslactomycin B (121) (a) and jerangolid A (122) (b). The heterocycle-forming steps ...
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a) Structures of rhizoxin (130) and cycloheximide (131). Model for the formation of δ-lactones (b) ...
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EncM catalyses a dual oxidation sequence and following processing of the highly reactive intermedia...
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Mesomeric structures of tetronates [138,139].
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Structures of tetronates for which gene clusters have been sequenced. The tetronate moiety is shown...
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Conserved steps for formation and processing in several 3-acyl-tetronate biosynthetic pathways were...
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In versipelostatin A (153) biosynthesis, VstJ is a candidate enzyme for catalysing the [4 + 2] cycl...
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a) Structures of some thiotetronate antibiotics. b) Biosynthesis of thiolactomycin (165) as propose...
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Aureusidine synthase (AS) catalyses phenolic oxidation and conjugate addition of chalcones leading ...
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a) Oxidative cyclisation is a key step in the biosynthesis of spirobenzofuranes 189, 192 and 193. b...
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A bicyclisation mechanism forms a β-lactone and a pyrrolidinone and removes the precursor from the ...
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Spontaneous cyclisation leads to off-loading of ebelactone A (201) from the PKS machinery .
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Mechanisms for the formation of nitrogen heterocycles.
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Biosynthesis of highly substituted α-pyridinones. a) Feeding experiments confirmed the polyketide o...
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Acridone synthase (ACS) catalyses the formation of 1,3-dihydroxy-N-methylacridone (224) by condensa...
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A Dieckmann condensation leads to the formation of a 3-acyl-4-hydroxypyridin-2-one 227 and removes ...
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a) Biosynthesis of the pyridinone tenellin (234). b) A radical mechanism was proposed for the ring-...
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a) Oxazole-containing PKS–NRPS-derived natural products oxazolomycin (244) and conglobatin (245). b...
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Structure of tetramic acids 251 (a) and major tautomers of 3-acyltetramic acids 252a–d (b). Adapted...
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Equisetin biosynthesis. R*: terminal reductive domain. Adapted from .
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a) Polyketides for which a similar biosynthetic logic was suggested. b) Pseurotin A (256) biosynthe...
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Representative examples of PTMs with varying ring sizes and oxidation patterns [205,206].
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Ikarugamycin biosynthesis. Adapted from [209-211].
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Tetramate formation in pyrroindomycin aglycone (279) biosynthesis [213-215].
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Dieckmann cyclases catalyse tetramate or 2-pyridone formation in the biosynthesis of, for example, ...
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Beilstein J. Org. Chem. 2016, 12, 1512–1550, doi:10.3762/bjoc.12.148
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