/ Home
/ SUBMISSION

/ The BJOC
/ Diamond Open Access
/ Journal Statistics
/ Editorial Board
/ Community
/ Call for papers

/ Latest Articles
/ Most accessed
/ Thematic issues
/ Volumes
/ Authors

/ E-Alerts

/ TWITTER
/ LINKEDIN
/ Mastodon
/ RSS FEED

Empty search

Article Type

Publication Date Range

Search Tips

This search combines search strings from the content search (i.e. "Full Text", "Author", "Title", "Abstract", or "Keywords") with "Article Type" and "Publication Date Range" using the AND operator.

Search Examples

aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)

BROWSE
Latest Articles
Most accessed
thematic issues
volumes
authors

BROWSE

Latest Articles Most Accessed Thematic Issues Volumes Authors

Author

Type 3 or more characters for results.

Type 2 or more characters for results.

Type 3 or more characters for results.

Type 2 or more characters for results.

2 article(s) from Hu, Xiang-Guo

Homologated amino acids with three vicinal fluorines positioned along the backbone: development of a stereoselective synthesis

Raju Cheerlavancha,
Ahmed Ahmed,
Yun Cheuk Leung,
Aggie Lawer,
Qing-Quan Liu,
Marina Cagnes,
Hee-Chan Jang,
Xiang-Guo Hu and
Luke Hunter

Beilstein J. Org. Chem. 2017, 13, 2316–2325, doi:10.3762/bjoc.13.228

PDF

Graphical Abstract

Figure 1: Examples of conformationally biased amino acids [1-10]. Compound 6 is a target of this work.

Jump to Figure 1

Scheme 1: The first synthetic approach.

Jump to Scheme 1

Scheme 2: The second synthetic approach.

Jump to Scheme 2

Scheme 3: The third synthetic approach.

Jump to Scheme 3

Scheme 4: The fourth synthetic approach (partially reproduced from ref. [17]).

Jump to Scheme 4

Figure 2: Selected J values and the inferred molecular conformations of 6a and 6b.

Jump to Figure 2

Album

Supp Info

Full Research Paper

Published 01 Nov 2017

Full text

Stereoselectively fluorinated N-heterocycles: a brief survey

Xiang-Guo Hu and
Luke Hunter

Beilstein J. Org. Chem. 2013, 9, 2696–2708, doi:10.3762/bjoc.9.306

PDF

Graphical Abstract

Figure 1: Fluorination alters the reactivity of aziridines.

Jump to Figure 1

Scheme 1: Fluorination makes β-lactam derivatives more reactive towards lipase-catalysed methanolysis.

Jump to Scheme 1

Figure 2: The ring pucker in azetidine derivatives can be influenced by a C–F^…N⁺ charge–dipole interaction.

Jump to Figure 2

Figure 3: Fluorination ridifies the pyrrolidine rings of ligand 10, with several consequences for its G-quadr...

Jump to Figure 3

Figure 4: Proline 11 readily undergoes a ring-flip process, but (4R)-fluoroproline 12 is more rigid because o...

Jump to Figure 4

Scheme 2: Hyperconjugation rigidifies the ring pucker of a fluorinated organocatalyst 14, leading to higher e...

Jump to Scheme 2

Figure 5: Fluorinated piperidines prefer the axial conformation, due to stabilising C–F^…N⁺ interactions.

Jump to Figure 5

Figure 6: Fluorination can rigidify a substituted azepane, but only if it acts in synergy with the other subs...

Jump to Figure 6

Figure 7: The eight-membered N-heterocycle 24 prefers an axial orientation of the fluorine substituent, givin...

Jump to Figure 7

Figure 8: Some iminosugars are “privileged structures” that serve as valuable drug leads.

Jump to Figure 8

Figure 9: Fluorinated iminosugar analogues 32–34 illuminate the binding interactions of the α-glycosidase inh...

Jump to Figure 9

Figure 10: Fluorinated miglitol analogues, and their inhibitory activity towards yeast α-glycosidase.

Jump to Figure 10

Figure 11: Analogues of isofagomine (31) have different pK_aH values, and therefore exhibit maximal β-glucosida...

Jump to Figure 11

Scheme 3: General strategy for the synthesis of fluorinated N-heterocycles via deoxyfluorination.

Jump to Scheme 3

Figure 12: Late stage deoxyfluorination in the synthesis of multifunctional N-heterocycles.

Jump to Figure 12

Scheme 4: During the deoxyfluorination of N-heterocycles, neighbouring group participation can sometimes lead...

Jump to Scheme 4

Scheme 5: A building block approach for the synthesis of fluorinated aziridines 2 and 3.

Jump to Scheme 5

Scheme 6: Building block approach for the synthesis of a difluorinated analogue of calystegine B (63).

Jump to Scheme 6

Scheme 7: Synthesis of fluorinated analogues of brevianamide E (65) and gypsetin (68) via electrophilic fluor...

Jump to Scheme 7

Scheme 8: Organocatalysed enantioselective fluorocyclisation.

Jump to Scheme 8

Scheme 9: Synthesis of 3-fluoroazetidine 73 via radical fluorination.

Jump to Scheme 9

Scheme 10: Synthesis of 3,3-difluoropyrrolidine 78 via a radical cyclisation.

Jump to Scheme 10

Scheme 11: Chemoenzymatic synthesis of fluorinated β-lactam 4b.

Jump to Scheme 11

Album

Review

Published 29 Nov 2013

Full text

Other Beilstein-Institut Open Science Activities

/ Help / Support & Contact / E-Alerts / Privacy Policy / Terms & Conditions / Impressum