2 article(s) from Hu, Xiang-Guo
Examples of conformationally biased amino acids [1-10]. Compound 6 is a target of this work.
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The first synthetic approach.
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The second synthetic approach.
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The third synthetic approach.
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The fourth synthetic approach (partially reproduced from ref. ).
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Selected J values and the inferred molecular conformations of 6a and 6b.
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Beilstein J. Org. Chem. 2017, 13, 2316–2325, doi:10.3762/bjoc.13.228
Fluorination alters the reactivity of aziridines.
Fluorination makes β-lactam derivatives more reactive towards lipase-catalysed methanolysis.
The ring pucker in azetidine derivatives can be influenced by a C–F…N+ charge–dipole interaction.
Fluorination ridifies the pyrrolidine rings of ligand 10, with several consequences for its G-quadr...
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Proline 11 readily undergoes a ring-flip process, but (4R)-fluoroproline 12 is more rigid because o...
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Hyperconjugation rigidifies the ring pucker of a fluorinated organocatalyst 14, leading to higher e...
Fluorinated piperidines prefer the axial conformation, due to stabilising C–F…N+ interactions.
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Fluorination can rigidify a substituted azepane, but only if it acts in synergy with the other subs...
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The eight-membered N-heterocycle 24 prefers an axial orientation of the fluorine substituent, givin...
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Some iminosugars are “privileged structures” that serve as valuable drug leads.
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Fluorinated iminosugar analogues 32–34 illuminate the binding interactions of the α-glycosidase inh...
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Fluorinated miglitol analogues, and their inhibitory activity towards yeast α-glycosidase.
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Analogues of isofagomine (31) have different pKaH values, and therefore exhibit maximal β-glucosida...
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General strategy for the synthesis of fluorinated N-heterocycles via deoxyfluorination.
Late stage deoxyfluorination in the synthesis of multifunctional N-heterocycles.
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During the deoxyfluorination of N-heterocycles, neighbouring group participation can sometimes lead...
A building block approach for the synthesis of fluorinated aziridines 2 and 3.
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Building block approach for the synthesis of a difluorinated analogue of calystegine B (63).
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Synthesis of fluorinated analogues of brevianamide E (65) and gypsetin (68) via electrophilic fluor...
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Organocatalysed enantioselective fluorocyclisation.
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Synthesis of 3-fluoroazetidine 73 via radical fluorination.
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Synthesis of 3,3-difluoropyrrolidine 78 via a radical cyclisation.
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Chemoenzymatic synthesis of fluorinated β-lactam 4b.
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Beilstein J. Org. Chem. 2013, 9, 2696–2708, doi:10.3762/bjoc.9.306
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