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Beilstein J. Org. Chem. 2021, 17, 319–324, doi:10.3762/bjoc.17.29
Graphical Abstract
Figure 1: Biologically active di- and tetrahydropyridazines.
Scheme 1: Recyclization of hydroxypyrrolines with hydrazine derivatives.
Scheme 2: Synthesis of tetrahydropyridazines 3.
Scheme 3: Synthesis of dihydropyridazines 4.
Scheme 4: Recyclization of hydroxypyrroline 1a with hydrazides 2d and 2e.
Scheme 5: A proposed mechanism for the recyclization of hydroxypyrrolines 1 with hydrazides 2.