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1 article(s) from Jirásko, Michal

Archangelolide: A sesquiterpene lactone with immunobiological potential from Laserpitium archangelica

Silvie Rimpelová,
Michal Jurášek,
Lucie Peterková,
Jiří Bejček,
Vojtěch Spiwok,
Miloš Majdl,
Michal Jirásko,
Miloš Buděšínský,
Juraj Harmatha,
Eva Kmoníčková,
Pavel Drašar and
Tomáš Ruml

Beilstein J. Org. Chem. 2019, 15, 1933–1944, doi:10.3762/bjoc.15.189

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Graphical Abstract

Figure 1: The structure of the sesquiterpene lactones archangelolide (1) and trilobolide (2).

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Scheme 1: Reagents and conditions: a) MeOH, TEA, 48 h, yield 32%; b) (i) 5-azidopentanoic acid, DCC, DCM, 90 ...

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Figure 2: Intracellular localization of archangelolide-dansyl (5) in human cells from osteosarcoma (U-2 OS). ...

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Figure 3: Co-localization of dansylarchangelolide 5 with a marker of endoplasmic reticulum (top row) and with...

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Figure 4: Cartoon representation of sarco/endoplasmic reticulum Ca²⁺ ATPase binding pocket with A, C) archang...

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Figure 5: Molecular surface representation of sarco/endoplasmic reticulum Ca²⁺ ATPase binding pocket with A) ...

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Figure 6: Structural formulae of (i) thapsigargin, (ii) trilobolide (2), and (iii) archangelolide (1). Red pa...

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Figure 7: Viability of rat peritoneal cells treated with archangelolide (1), dansylarchangelolide 5 and dansy...

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Figure 8: NO production in primary rat macrophages. The cells were treated with archangelolide (1) and dansyl...

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Figure 9: Evaluation of cytokine TNF-α secretion in rat peritoneal cells. Stimulation of primary cells was in...

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Figure 10: Structure of laserolide.

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Published 13 Aug 2019

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