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Beilstein J. Org. Chem. 2026, 22, 535–546, doi:10.3762/bjoc.22.39
Graphical Abstract
Figure 1: Structures of isomeric melifoliones and corresponding oxidation products.
Scheme 1: Synthesis of melifoliones and by-products: a) pyridine/60 °C/8 h/51%, b) microwave/140 °C/20 min/70...
Figure 2: Structure of iodized melifoliones.
Scheme 2: Reaction of melifolione A (1) with iodosobenzene diacetate.
Scheme 3: Hypothetical pathway for the oxidative ring contraction of melifolione A (1) with ferricyanide/hydr...
Figure 3: Left Part: 11 (main fraction); Right part: 12 (side product).
Scheme 4: Oxidative ring contraction of melifolione B (2).
Scheme 5: Alternative routes to the spirofuranones 11 and 12 via hypothetical pyranone epoxides 13 and 14.