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Beilstein J. Org. Chem. 2026, 22, 592–602, doi:10.3762/bjoc.22.45
Graphical Abstract
Figure 1: Examples of sulfonylisoxazoles with biological activities.
Scheme 1: Reactions for preparing 5-sulfonylisoxazoles.
Scheme 2: Scope of 5-nitroisoxazoles 1a–g in the reaction with thiophenols.
Scheme 3: Scope of 5-thioisoxazoles 2a-p in the reaction with mCPBA.
Scheme 4: Oxidation of 5-thioisoxazoles into 5-sulfinylisoxazoles.
Figure 2: The samples of isoxazole derivatives trigger SOS response in E. coli reporter strains. A) Agar plat...
Figure 3: Inhibition of Klenow fragment of E. coli DNA polymerase I. A) The principal scheme of the Klenow fr...
Figure 4: Inhibition of E. coli DNA gyrase and Topo IV cleavage activity. A) The principal scheme of E. coli ...
Figure 5: Inhibition of E. coli DNA Topo I cleavage activity. A) The principal scheme of E. coli DNA Topo I c...
Figure 6: Inhibition of E. coli DNA gyrase supercoiling activity. A) The principal scheme of E. coli DNA gyra...
Figure 7: Inhibition of E. coli DNA Topo IV decatenation activity. A) The principal scheme of of E. coli DNA ...