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Beilstein J. Org. Chem. 2025, 21, 800–806, doi:10.3762/bjoc.21.63
Graphical Abstract
Scheme 1: Synthesis of acyclic nitrile-substituted quaternary carbon centers from allenes.
Scheme 2: Hydrocyanation of allene 1a with tosyl cyanide.
Scheme 3: Hydrocyanation with various di- or trisubstituted allenes. Reaction conditions: allene 1 (0.3 mmol)...
Scheme 4: Hydrocyanation with various monosubstituted allenes. Reaction conditions: allene 4 (0.3 mmol), (iBu)...
Scheme 5: Gram scale reaction.
Scheme 6: Synthetic applications.
Scheme 7: Proposed mechanism.