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Beilstein J. Org. Chem. 2026, 22, 123–130, doi:10.3762/bjoc.22.5
Graphical Abstract
Figure 1: Two natural trichloromethyl-containing compounds.
Scheme 1: Approaches to the synthesis of vic-trifluoromethylnitrocyclopropanes.
Scheme 2: Synthesis of monocyclic trichloromethylnitrocyclopropanes 2–5.
Scheme 3: Synthesis of spiro-fused trichloromethylnitrocyclopropane 6.
Scheme 4: Synthesis of spiro-fused trichloromethylnitrocyclopropanes 7–9. i: 1.5 AcOK, MeOH, rt, 3 h.
Scheme 5: Main NOE correlations in 9a, 9b.
Scheme 6: Proposed mechanism of the formation of trichloromethylnitrocyclopropanes.
Figure 2: Geometry of 2 in the crystal.
Figure 3: Geometry of 3 in the crystal.
Figure 4: Geometry of 9a in the crystal.
Figure 5: Geometry of 9b in the crystal.
Beilstein J. Org. Chem. 2025, 21, 340–347, doi:10.3762/bjoc.21.24
Scheme 1: Approaches to the synthesis of naphtho[2,3-b]furan-4,9-diones.
Scheme 2: Approaches to the synthesis of furo[2,3-d]pyrimidin-4(3H)-ones.
Scheme 3: Approaches to the synthesis of furan-containing pyranopyrans and pyranochromenes.
Scheme 4: Reaction of alkyl 3-bromo-3-nitroacrylates 1a,b with 2-hydroxynaphthalene-1,4-dione (2a).
Scheme 5: Reaction of alkyl 3-bromo-3-nitroacrylates 1a,b with 4-hydroxy-7,7-dimethyl-7,8-dihydro-2H-1-benzop...
Scheme 6: Reaction of alkyl 3-bromo-3-nitroacrylates 1a,b with 4-hydroxy-7-methyl-2H,5H-pyrano[4,3-b]pyran-2,...
Scheme 7: Reaction of alkyl 3-bromo-3-nitroacrylates 1a,b with pyrimidine-4,6-diols 2e–g.