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1 article(s) from Lu, Si-Ran

Research progress on calixarene/pillararene-based controlled drug release systems

Liu-Huan Yi,
Jian Qin,
Si-Ran Lu,
Liu-Pan Yang,
Li-Li Wang and
Huan Yao

Beilstein J. Org. Chem. 2025, 21, 1757–1785, doi:10.3762/bjoc.21.139

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Graphical Abstract

Figure 1: Schematic diagram of drug-controlled release mechanisms based on aromatic macrocycles.

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Figure 2: Chemical structure of a) calix[n]arene (m = 1,3,5), and b) pillar[n]arene (m = 1,2,3).

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Figure 3: Changes in pH conditions cause the release of drugs from CA8 host–guest complexes [101]. Figure 3 was adapted wi...

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Figure 4: The illustration of the pH-mediated 1:1 complex formation between the host and guest molecules in a...

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Figure 5: Illustration of the pH-responsive self-assembly of mannose-modified CA4 into micelles and the subse...

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Figure 6: Illustration of the assembly of supramolecular prodrug nanoparticles from WP6 and DOX-derived prodr...

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Figure 7: Illustration of the formation of supramolecular vesicles and their pH-dependent drug release [93]. Figure 7 was...

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Figure 8: Schematic illustration of the application of the multifunctional nanoplatform CyCA@POPD in combined...

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Figure 9: Illustration of the photolysis of an amphiphilic assembly via CA-induced aggregation [114]. Figure 9 was reprint...

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Figure 10: Schematic illustration of drug release controlled by the photo-responsive macroscopic switch based ...

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Figure 11: Schematic illustration of the formation process of Azo-SMX and its photoisomerization reaction unde...

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Figure 12: Schematic illustration of the enzyme-responsive behavior of supramolecular polymers [95]. Figure 12 was used wit...

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Figure 13: Schematic illustration of the amphiphilic assembly of SC4A and its enzyme-responsive applications [119]. ...

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Figure 14: Stimuli-responsive nanovalves based on MSNs and choline-SC4A[2]pseudorotaxanes, MSN-C1 with ester-l...

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Figure 15: A schematic diagram showing the construction of a supramolecular system by host–guest interaction b...

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Figure 16: A schematic diagram showing the formation of the host–guest complex DOX@Biotin-SAC4A by biotin modi...

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Figure 17: A schematic diagram showing the self-assembly of CA4 into a hypoxia-responsive peptide hydrogel, wh...

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Figure 18: Schematic illustration of the formation process of Lip@GluAC4A and the release of Lip under hypoxic...

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Figure 19: Schematic illustration of the construction of a supramolecular vesicle based on the host–guest comp...

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Figure 20: Schematic illustration of WP6 self-assembly at pH > 7, and the stimulus-responsive drug release beh...

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Figure 21: Schematic illustration of the formation of supramolecular vesicles based on the WP5⊃G super-amphiph...

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Figure 22: Schematic illustrations of the host–guest recognition of QAP5⊃SXD, the formation of the nanoparticl...

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Figure 23: Schematic illustration of the activation of T-SRNs by acid, alkali, or Zn²⁺ stimuli to regulate the...

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Figure 24: Illustration of the triggered release of BH from CP[5]A@MSNs-Q NPs in response to a drop in pH or a...

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Figure 25: Illustration of the supramolecular amphiphiles TPENC_n@1 (n = 6 and 12) self-assembling with disulfi...

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Review

Published 03 Sep 2025

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