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Beilstein J. Org. Chem. 2025, 21, 2513–2523, doi:10.3762/bjoc.21.193
Graphical Abstract
Figure 1: (a) Structure of a PNA oligomer with the N-(2-aminoethyl)glycine backbone (in red); (b) Representat...
Figure 2: Representative extended nucleobase triples through Hoogsteen hydrogen bonding (blue dashed lines). ...
Figure 3: Evolution of the strategy for U–A recognition.
Figure 4: Isoorotamide-derived nucleobases for A–U recognition.
Figure 5: Proposed isoorotamide distal binding (Db) nucleobases designed from the Io5 core. Hydrogen bonding ...
Scheme 1: Synthesis of the Db1 monomer (8).
Scheme 2: Synthesis of Db2 monomer 15.
Scheme 3: Synthesis of Db3 monomer 21.
Figure 6: Sequences for RNA hairpins and PNA ligands used for binding studies.
Figure 7: Major-groove view of hydrogen-bonding interactions in the (A) Db1*U–A triplet, (B) Db2*U–A triplet,...