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Beilstein J. Org. Chem. 2025, 21, 1544–1551, doi:10.3762/bjoc.21.117
Graphical Abstract
Scheme 1: Synthesis of CyreneTM (dihydrolevoglucosenone) from cellulose-based feeds via levoglucosenone (LG).
Scheme 2: Copper-catalyzed azide–alkyne cycloaddition of benzyl azide (1a) and phenylacetylene (2a) in variou...
Figure 1: Comparison of various solvents used in the CuAAC reaction. Reaction conditions: 1.15 mmol benzyl az...
Figure 2: Effect of the Cu source used in the click reaction of benzyl azide (1a, 1.15 mmol) and phenylacetyl...
Figure 3: Copper-catalyzed azide–alkyne cycloaddition of benzyl azide (1a) and various acetylenes 2a–h in Cyr...
Figure 4: Consecutive synthesis of various N-substituted-4-phenyl-1H-1,2,3-triazoles in CyreneTM. Reaction co...
Figure 5: “One-pot” synthesis of various 1-allyl-4-substituted-1H-1,2,3-triazoles in CyreneTM. Reaction condi...
Figure 6: Solvent recovery for the CuAAC reaction of 1a and 2a. Reaction conditions: 12.5 mL CyreneTM, 1 mol ...