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1 article(s) from Mohammed, Pshtiwan S.

Synthesis of novel 1,2,4-oxadiazole-isoxazoline hybrids and their in silico potential with adenosine receptors

Pshtiwan S. Mohammed,
Mohammed K. S. Dalo,
Onur C. Yazıcı,
Muhammet Yildirim and
Akın Sağırlı

Beilstein J. Org. Chem. 2026, 22, 1033–1047, doi:10.3762/bjoc.22.82

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Figure 1: General structure of isoxazoline, 1,2,4-oxadiazole and biologically active 1,2,4-oxadizole, isoxazo...

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Scheme 1: Recent studies for the synthesis of 1,2,4-oxadiazole-isoxazoline hybrids.

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Figure 2: Various adenosine receptor (AR) antagonists, catechol-O-methyltransferase (COMT) and 1,2,4-oxadiazo...

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Scheme 2: Synthesis of novel 1,2,4-oxadiazole-isoxazoline lead compounds by 1,3-DC.

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Scheme 3: Synthetic methods for accessing the starting compounds (2a–k, 6a–j). Reagents and conditions: a) NH₂...

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Scheme 4: Mechanism for the formation of novel 3,5-disubstituted 1,2,4-oxadiazolyl diarylisoxazolines 7a–ay (...

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Figure 3: 3D and 2D binding interactions of best scoring compounds (7x-(S), 7x-(R), 7j-(S), 7aw-(S), 7aw-(R),...

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Published 06 Jul 2026

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