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1 article(s) from Opara, Karina

Molecular tweezer–peptide conjugates disrupt the protein–protein interaction between survivin and histone H3 essential in mitosis

Catherine Gsell,
Philipp Rebmann,
Karina Opara,
Christine Beuck,
Peter Bayer,
David Bier,
Ingrid R. Vetter and
Thomas Schrader

Beilstein J. Org. Chem. 2026, 22, 557–567, doi:10.3762/bjoc.22.41

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Figure 1: Mechanism of CPC recruitment to centromeres and kinetochores. A) Initially phosphomarks are placed ...

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Figure 2: Ribbon model of crystal structure PDB ID 4A0J (https://doi.org/10.2210/pdb4A0J/pdb) [8] of survivin (o...

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Scheme 1: A) Peptide tweezer conjugates 1 and 2a with triazoles linking the tweezer and H3 peptide at its C-t...

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Figure 3: Survivin complexes with peptide tweezers: Fluorescence polarization measurements of wild type and m...

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Figure 4: Crystal structure of the survivin dimer with complexed tweezer H3 conjugate 2a. To distinguish both...

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Figure 5: Survivin–borealin–INCENP complex structures (PDB ID 2QFA) [5] with tweezer model, side and top views. ...

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Figure 6: A) Lewis structure of the truncated tweezer peptide monophosphate 2b. B) Close-up of the binding mo...

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Scheme 2: A) Lewis structures of the new slightly extended binding peptide 3b and the respective click conjug...

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Published 27 Mar 2026

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