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Beilstein J. Org. Chem. 2026, 22, 480–485, doi:10.3762/bjoc.22.35
Graphical Abstract
Figure 1: HDAC1–3 inhibitor CI-994; HDAC inhibitor–nanogold probe Au–(CI-994); structure of amine-functionali...
Scheme 1: Synthesis of CI-994 and the Au–(CI-994) conjugate. Conditions: a) Boc2O, NEt3, THF, 0 °C to rt, 19 ...
Figure 2: Left: Single point concentration HDAC assay. Concentration of Au–NH2 and Au–(CI-994) = 0.54 µM. Con...
Figure 3: Final round of 2D classification of the cross-linked CoREST complex in the presence of Au–(CI-994) ...