2 article(s) from Raz, Keren
Mechanism for formation of cyclooctat-9-en-7-ol, published similarly in .
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Computed electronic energy profiles (kcal/mol) for the CotB2 cyclase mechanism. The calculations us...
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Intermediates A–I in the active site model. Interactions are marked by dashed orange lines, the int...
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TS structures TS_A_B–TS_G/H_I in the active site model. Interactions are marked by dashed orange li...
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Comparison between gas phase and active site model conformations. A) Intermediate D. B) Intermediat...
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Beilstein J. Org. Chem. 2020, 16, 50–59, doi:10.3762/bjoc.16.7
CotB1 synthesizes geranylgeranyl diphosphate (GGDP) 3 from the substrates dimethylallyl diphosphate...
The bacterial diterpene synthase CotB2wt·Mg2+3·F-Dola in the closed, active conformation (PDB-ID 6G...
Conformational changes of CotB2 upon ligand binding. Superposition of CotB2’s open (teal), pre-cata...
View into the active site of CotB2wt·Mg2+3·F-Dola  superimposed with CotB2wt·Mg2+B·GGSDP . (A) The ...
View into the active site of CotB2wt·Mg2+3·F-Dola . Identical view as in Figure 4. (A) The bound F-Dola rea...
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The WXXXXXRY motif in protein sequences of diterpene TPS from different bacteria. Highlighted is th...
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Overview of the altered product portfolio as a result of introduced point mutations in the active s...
Catalytic mechanism of CotB2, derived from isotope labeling experiments [34,35], density functional theory...
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(A) The inner surface of the active site is shown in gray. The bound F-Dola reaction intermediate i...
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Variants of CotB2 open the route to a novel product portfolio with altered cyclic carbon skeletons,...
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Beilstein J. Org. Chem. 2019, 15, 2355–2368, doi:10.3762/bjoc.15.228
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