1 article(s) from Reimann, Marcel
- Full Research Paper
- Published 20 Jul 2017
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Graphical Abstract
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Figure 1: Structure of fusaricidins E (1) and F (2).
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Figure 2: NOESY /COSY and HMBC correlations of compound 1.
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Figure 3: Fragmentation pattern of compounds 1 and 2.
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Scheme 1: Retrosynthetic plan for the depsipeptide and GHPD side chain.
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Scheme 2: a) LiAlH4, THF, reflux, 12 h, quant.; b) Fmoc-OSu, NaHCO3, 1,4-dioxane, H2O, 0 °C to rt, 87%; c) 1:...
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Scheme 3: Ester bond formation with 2,2-dimethylated pseudoproline including peptide 16.
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Scheme 4: Cyclization with 2,2-dimethylated pseudoproline including peptide 16.
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Scheme 5: Depsipeptide cyclization and coupling with GHPD side chain.
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Figure 4: Byproducts from removal of Cbz group in THF and DMF.
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