Co-crystallization of an organic solid and a tetraaryladamantane at room temperature

Fabian Rami,
Jan Nowak,
Felix Krupp,
Wolfgang Frey and
Clemens Richert

Letter
Published 21 Jun 2021

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1. Graphical Abstract
2. Figure 1: Structure of TDA and TEO, the crystallization hosts used for co-crystallization.
  
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3. Figure 2: Details of the X-ray crystal structures obtained, shown as ORTEP plots at 50% probability, with van...
  
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4. Figure 3: Possible states of two organic compounds capable of crystallizing at room temperature in a solvent....
  
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Beilstein J. Org. Chem. 2021, 17, 1476–1480, doi:10.3762/bjoc.17.103

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Enzyme-free genetic copying of DNA and RNA sequences

Marilyne Sosson and
Clemens Richert

Review
Published 12 Mar 2018

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1. Graphical Abstract
2. Figure 1: Enzyme-free template-directed extension of an RNA primer by one nucleotide. B = nucleobase, LG = le...
  
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3. Figure 2: Oligomerization of the 2-methylimidazolide of guanosine-5'-monophosphate on a poly(C) template.
  
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4. Figure 3: Structures of backbone linkages produced in enzyme-free primer extension reactions: the phosphorami...
  
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5. Figure 4: System used for studying the template effect with all 64 possible triplets at the extension site (B...
  
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6. Figure 5: Interactions attracting the incoming nucleotide to the extension site. Besides base pairing via hyd...
  
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7. Figure 6: Three possible fates of activated nucleotides in aqueous buffer that result from hydrolysis, primer...
  
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8. Figure 7: Steps and equilibria considered in our quantitative model of chemical primer extension [34]. The model ...
  
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9. Figure 8: Binding equilibrium between mononucleotides and hairpins representing primer–template duplexes, as ...
  
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10. Figure 9: Template-directed primer extension on an RNA template performed with OAt-GMP at 1.8 mM (orange), 3....
  
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11. Figure 10: Copying of four nucleotides on an immobilized RNA duplex, as reported by Deck et al. [32].
  
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12. Figure 11: Extension cycle of aminoterminal primer with N-protected nucleotides on solid support, as described...
  
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13. Figure 12: Formation of a highly reactive methylimidazolium bisphosphate from methylimidazolides of nucleotide...
  
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14. Figure 13: ³¹P NMR spectrum (161.9 MHz) of crude MeIm-GMP in D₂O. The resonance of the imidazolium bisphosphat...
  
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15. Figure 14: Imidazolium bisphosphate as intermediate in the primer extension reaction, as described by Szostak ...
  
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16. Figure 15: Proposed steps of enzyme-free primer extension with in situ activation, using the "general condensa...
  
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