2 article(s) from Rosemeyer, Helmut
General structure of the fluorophore-labeled lipo-oligonucleotides and positions of lipophilization...
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Chemical formulae 1–9 and lipo-oligonucleotide sequences 10–15.
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Energy-minimized 3D structures of the lipophilic nucleoside headgroups 4a–9a. All 3D structures wer...
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Schematic display of the three main equilibria existing on the cis side of the bilayer chamber.
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Bilayer brightness vs event graph of 5’-d(4a-Cy5-TAG GTC AAT ACT) (10).
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Bilayer brightness vs event graph of 5’-d(5a-Cy5-TAG GTC AAT ACT) (11).
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Bilayer brightness vs event graph of 5’-d(6a-Cy5-TAG GTC AAT ACT) (12).
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Bilayer brightness vs event graph of 5’-d(7a-Cy5-TAG GTC AAT ACT) (13).
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Infiltration of lipo-oligonucleotide (13) aggregates from the buffer into the lipid bilayer. Z-dire...
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Bilayer brightness vs event graph of 5’-d(8a-Cy5-TAG GTC AAT ACT) (14).
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Bilayer brightness vs event graph of 5’-d(9a-Cy5-TAG GTC AAT ACT) (15).
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Summarizing the bilayer brightness for LONs 10–15 depending on the incubation time up to the maximu...
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Diffusion time measurements of LON 10 (5 µL, 50 nM). A) Z-direction scan directly after the additio...
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Hydrodynamic models of lipophilic oligonucleotides 10–15. Views are perpendicular (right) or parall...
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Scheme of a stretched rotation ellipsoid with the semi-major axes a and b.
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Schematic structure of a Cy5-labeled lipo-oligonucleotide.
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Fluorescence lifetime τF values of the LONs 10–15. A) Logarithmic imaging of fluorescence intensity...
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Beilstein J. Org. Chem. 2015, 11, 913–929, doi:10.3762/bjoc.11.103
Chemical formulae and lipo-oligonucleotide sequences.
Schematic illustrations (experiments A–F) of the specific DNA duplex formation at artificial lipid ...
Experimental setup. Schematic drawing of the laser scanning microscope, the optical transparent mic...
Chronological protocol of duplex formation of the lipo-oligonucleotide 4 with the complementary Cy5...
Comparison of the bilayer brightness intensity with either Cy5 (irradiation: 635 nm) or Sybr Green ...
Scheme of a z-scan of a lipid bilayer showing two locations for measurements of the diffusion times...
Experiment B (4 + 6 + SG). Bilayer brightness as function of the various events (addition of oligon...
Experiment D (4 + 9 + SG). Bilayer brightness as function of time and the various events [addition ...
Conceivable geometry of the complex at the bilayer surface (cis compartment).
Experiment E (10 + 6 + SG). Bilayer brightness as a function of time as well as of various events [...
Experiment E (10 + 6 + SG). Bilayer brightness as function of the incubation time (A), of the perfu...
Z-scans of the experiment E before and after the addition of Sybr Green I. A) Z-scan after the addi...
Experiment E in reversed order of component addition; SG + 10 + 6.
Bilayer brightness as a function of perfusion number and incubation periods for the experiment E in...
Bilayer brightness as a function of perfusion number and incubation periods for the experiment F (SG...
Kinetics of the tertiary complex formations of various lipo-DNA/DNA with Sybr Green I during incuba...
Trafficking of a siRNA by a lipophilized DNA.
A) Stage unit of the ‘Ionovation Explorer’ mounted on a standard inverted fluorescence microscope. ...
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Beilstein J. Org. Chem. 2014, 10, 2307–2321, doi:10.3762/bjoc.10.240
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