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Beilstein J. Org. Chem. 2026, 22, 244–256, doi:10.3762/bjoc.22.18
Graphical Abstract
Figure 1: Examples of biologically active quinolin-2(1H)-ones.
Figure 2: Structures obtained via rational design aimed at enhancing antibacterial activity.
Scheme 1: Previously reported and newly developed 3-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-3-arylpropanoi...
Scheme 2: Retrosynthetic analysis: two alternative approaches to target compounds.
Scheme 3: Two-stage synthesis A) and one-stage one-pot synthesis B) of 6-halogen-4-hydroxyquinoline-2(1H)-one...
Scheme 4: Previous synthetic attempts toward the target chemotype using various approaches.
Scheme 5: Four-component synthesis of 3-(6-halo-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-3-(3,4-dimethoxyphe...
Scheme 6: The proposed mechanism of the four-component reaction.
Scheme 7: Synthesis of isopropyl (12a–c) and cyclohexyl (13а–с) esters of 3-(4-hydroxy-2-oxo-1,2-dihydroquino...
Figure 3: In vitro antibacterial activity studies. А) In vitro antibacterial activity using the E. coli ΔtolC...