1 article(s) from Sosson, Marilyne
- Review
- Published 12 Mar 2018
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Graphical Abstract
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Figure 1: Enzyme-free template-directed extension of an RNA primer by one nucleotide. B = nucleobase, LG = le...
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Figure 2: Oligomerization of the 2-methylimidazolide of guanosine-5'-monophosphate on a poly(C) template.
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Figure 3: Structures of backbone linkages produced in enzyme-free primer extension reactions: the phosphorami...
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Figure 4: System used for studying the template effect with all 64 possible triplets at the extension site (B...
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Figure 5: Interactions attracting the incoming nucleotide to the extension site. Besides base pairing via hyd...
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Figure 6: Three possible fates of activated nucleotides in aqueous buffer that result from hydrolysis, primer...
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Figure 7: Steps and equilibria considered in our quantitative model of chemical primer extension [34]. The model ...
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Figure 8: Binding equilibrium between mononucleotides and hairpins representing primer–template duplexes, as ...
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Figure 9: Template-directed primer extension on an RNA template performed with OAt-GMP at 1.8 mM (orange), 3....
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Figure 10: Copying of four nucleotides on an immobilized RNA duplex, as reported by Deck et al. [32].
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Figure 11: Extension cycle of aminoterminal primer with N-protected nucleotides on solid support, as described...
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Figure 12: Formation of a highly reactive methylimidazolium bisphosphate from methylimidazolides of nucleotide...
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Figure 13: 31P NMR spectrum (161.9 MHz) of crude MeIm-GMP in D2O. The resonance of the imidazolium bisphosphat...
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Figure 14: Imidazolium bisphosphate as intermediate in the primer extension reaction, as described by Szostak ...
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Figure 15: Proposed steps of enzyme-free primer extension with in situ activation, using the "general condensa...
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