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Beilstein J. Org. Chem. 2026, 22, 1221–1228, doi:10.3762/bjoc.22.98
Graphical Abstract
Scheme 1: a) Intra- and intermolecular reactivity of α-indolylalkenylgold carbenes from 3-propargylindoles. b...
Scheme 2: Proof of concept.
Scheme 3: Further catalyst screening with 1b.
Scheme 4: Substrate scope: variation of the propargylic position.
Scheme 5: Limitations and reactivity of methyl-substituted alkyne 5d.
Scheme 6: Further experiments: deuteration, gram-scale and competitive inter- vs intramolecular reaction.
Scheme 7: Alcohols as external nucleophiles. Synthesis of methoxy-functionalized indoles 10.