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Beilstein J. Org. Chem. 2025, 21, 2062–2071, doi:10.3762/bjoc.21.161
Graphical Abstract
Figure 1: Structure of indolo[1,2-c]quinazoline, its selected derivatives, and related structures with biolog...
Scheme 1: Synthesis of 12-modified indolo[1,2-c]quinazoline derivatives.
Scheme 2: Synthesis of indolo[1,2-c]quinazoline-12-carboxamides 7a–c.
Scheme 3: Mannich aminomethylation of indolo[1,2-c]quinazolines 1 and 8.
Scheme 4: Synthesis of 5-(3-aminopropyl) derivatives of indolo[1,2-c]quinazolin-6(5H)-one 12a–c.
Scheme 5: Synthesis of derivatives of 6-(aminomethyl)indolo[1,2-c]quinazolines 14a–d.
Figure 2: Fluorescence quenching of compounds 7a–c (2 μM) upon titration with calf thymus DNA (0–290 μM base ...