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1 article(s) from Toepp, Angela

Design and synthesis of multivalent α-1,2-trimannose-linked bioerodible microparticles for applications in immune response studies of Leishmania major infection

Chelsea L. Rintelmann,
Tara Grinnage-Pulley,
Kathleen Ross,
Daniel E. K. Kabotso,
Angela Toepp,
Anne Cowell,
Christine Petersen,
Balaji Narasimhan and
Nicola Pohl

Full Research Paper
Published 11 Mar 2019

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1. Graphical Abstract
2. Figure 1: Leishmania lipophosphoglycan (LPG), with Gal-β-(1→4)-[Man-α-(1→2)-Man-α-(1→2)-Man] variant capping ...
  
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3. Figure 2: Pathogen-associated bioerodible microparticles 2 and trimannose-coated latex beads 1.
  
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4. Figure 3: General design of the bioerodible microparticles.
  
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5. Scheme 1: Synthesis of fluorous CbzF-protected aminopentanol spacer 7.
  
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6. Scheme 2: Iterative synthesis of α-1,2-trimannose 16. Reagents and conditions: a) 1 M NaOH, MeOH or NaOMe.
  
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7. Scheme 3: Synthesis of bioerodible microparticle 2. Reagents and conditions: a) Et₂NH, CH₃CN, b) CH₂Cl₂/TFE/A...
  
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8. Figure 4: Trimannose-linked bioerodible microparticle 2 treatment of Leishmania major infected wild-type and ...
  
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Graphical Abstract

Beilstein J. Org. Chem. 2019, 15, 623–632, doi:10.3762/bjoc.15.58

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