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Beilstein J. Org. Chem. 2026, 22, 583–591, doi:10.3762/bjoc.22.44
Graphical Abstract
Figure 1: Chemical structures of severel FGFR inhibitors and degraders.
Figure 2: Rationale of the FGFR2 degrader design. a) Structure of the erdafitinib–FGFR complex. The figure wa...
Scheme 1: Synthesis of PROTACs towards FGFR2. Reagents and conditions: (a) K2CO3, Pd (dppf)Cl2, 1,4-dioxane/H2...
Figure 3: a) Representative western blots evaluating the total FGFR2 levels in KATO III cells following treat...
Figure 4: a) FGFR1, FGFR2, FGFR3, and FGFR4 levels in cells after treatment. b) The mechanism of PROTAC. It w...