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Beilstein J. Org. Chem. 2026, 22, 888–896, doi:10.3762/bjoc.22.69
Graphical Abstract
Figure 1: Bioactive molecules with benzofuran and pyroglutamic acid motif.
Figure 2: CSB-1-catalyzed Michael reactions of α,β-unsaturated compouds with glycine benzophenone-imine ester...
Scheme 1: Chiral base-catalyzed Michael reaction of 1a and 2a.
Scheme 2: The preparation of β-substituted α,β-unsaturated pyrazolamides 5.
Figure 3: The catalysts used in the screening of Michael reaction conditions.
Scheme 3: CSB-1-catalyzed Michael additions between compounds compounds 2 and 5.
Figure 4: The proposed attack modes of Michael addition of 2a and 5a.
Figure 5: A proposed reaction mechanism of CSB-1 catalyzed Michael reaction between 2a and 5a.
Scheme 4: In situ acidic hydrolysis and lactamization of 6.
Figure 6: Configuration of 7d’ determined by X-ray diffraction analysis.