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1 article(s) from Yang, Luxi

Advantages of PROTACs in achieving selective degradation of homologous protein families

Luxi Yang,
Xinfei Mao,
Jingyi Zhang,
Jing Shu,
Wenhai Huang,
Xiaowu Dong,
Yinqiao Chen and
Mingfei Wu

Beilstein J. Org. Chem. 2026, 22, 628–661, doi:10.3762/bjoc.22.49

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Graphical Abstract

Figure 1: Mechanism of a PROTAC-mediated targeted protein degradation. Created in BioRender. Wu, M. (2026) ht...

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Figure 2: CDK4/6 PROTACs with alkyl or PEG chains as linkers.

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Figure 3: CDK4/6 PROTACs with triazole-containing linkers.

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Figure 4: Structures of AT-7519 (7) and FN-1501 (8), and CDK9 degrading PROTACs based on compound 8 with vari...

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Figure 5: CDK9 PROTACs with alkane chain as linkers or triazole linkers.

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Figure 6: Structures of HDAC6 inhibitors ACY1215 (17) and ACY-241 (18), as well as the structure of PROTACs 1...

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Figure 7: C4-linked-series and C5-linked-series of HDAC6 PROTACs.

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Figure 8: Structures of VHL-based degraders.

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Figure 9: Structures of VHL-based and CRBN-based selective HDAC PROTACs.

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Figure 10: Structures of the “amide series” and “phenyl series” PROTACs studied by Crews et al.

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Figure 11: Structures of the “amide series” PROTACs.

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Figure 12: Structures of the “phenyl series” PROTACs.

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Figure 13: Structures of JQ1 (34) and MZ1 (35).

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Figure 14: Structures of macro-PROTAC-1 and SHD913.

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Figure 15: Commonly utilized thalidomide-derived CRBN ligands and possible linker attachment styles. A1, A2: p...

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Figure 16: VHL ligands frequently used in PROTACs. Linker attachment options are represented with curly bonds ...

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Figure 17: Varying the inhibitor warhead and the recruited E3 ligase permits targets to be accessed for degrad...

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Figure 18: Structures of YX-2-233 (42) and YX-2-107 (43).

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Figure 19: Structures of compounds 44 and 45.

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Figure 20: Design of the SGK3 PROTACs.

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Figure 21: CRBN, VHL, and IAP ligands used when designing HDAC-PROTACs.

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Figure 22: CDK4/6-PROTACs with different E3 ligands targeting the same E3 ubiquitin ligase.

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Figure 23: Structural basis for the selective degradation of CDK6 over CDK4 by PROTAC 2. (A) CDK4–molecule 2–C...

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Figure 24: Regarding the PPI-driven selectivity mechanism of two PROTAC molecules, SJF-α and SJF-δ, for p38α a...

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Figure 25: Co-crystal structure and ultra-high selectivity of the STAT6 PROTAC degrader AK-1690. (A) STAT6–AK-...

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Review

Published 27 Apr 2026

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