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Beilstein J. Org. Chem. 2026, 22, 888–896, doi:10.3762/bjoc.22.69
Graphical Abstract
Figure 1: Bioactive molecules with benzofuran and pyroglutamic acid motif.
Figure 2: CSB-1-catalyzed Michael reactions of α,β-unsaturated compouds with glycine benzophenone-imine ester...
Scheme 1: Chiral base-catalyzed Michael reaction of 1a and 2a.
Scheme 2: The preparation of β-substituted α,β-unsaturated pyrazolamides 5.
Figure 3: The catalysts used in the screening of Michael reaction conditions.
Scheme 3: CSB-1-catalyzed Michael additions between compounds compounds 2 and 5.
Figure 4: The proposed attack modes of Michael addition of 2a and 5a.
Figure 5: A proposed reaction mechanism of CSB-1 catalyzed Michael reaction between 2a and 5a.
Scheme 4: In situ acidic hydrolysis and lactamization of 6.
Figure 6: Configuration of 7d’ determined by X-ray diffraction analysis.
Beilstein J. Org. Chem. 2025, 21, 1678–1699, doi:10.3762/bjoc.21.132
Figure 1: Three key dimensions of a complete nitration process.
Figure 2: A typical continuous-flow nitration reaction system.
Figure 3: Corrosion characteristics of common wetted materials used in continuous-flow nitration system. Note...
Figure 4: Analysis of the literature on continuous-flow nitration reaction over the past decade.
Scheme 1: Model reaction for the homogeneous nitration by nitric acid/mixed acid.
Figure 5: Safety assessment criteria for nitration reactions. Notes: apressure-independent; bno hazards arisi...
Figure 6: Guide for the investigation of continuous-flow nitration processes.