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Beilstein J. Org. Chem. 2025, 21, 1661–1670, doi:10.3762/bjoc.21.130
Graphical Abstract
Scheme 1: Rationale of the current study: a) Our previous work [20]; b) this work.
Scheme 2: Comparison of KH2PO2 and NaH2PO2 under the optimal conditions.
Figure 1: Substrate scope. Reaction conditions: carbonyl compound (1.45 mmol, 1 equiv), amine (1.81 mmol, 1.2...
Scheme 3: Control experiments.
Scheme 4: Experiments with D3PO2.
Scheme 5: Principal steps of the mechanism of the reductive amination with K2CO3/H3PO2 reducing system.
Figure 2: Reaction profile and DFT energies of intermediates and transition states. M062X functional with the...