Beilstein J. Org. Chem.2012,8, 2184–2190, doi:10.3762/bjoc.8.246
been used for reversible manipulation of biological targets, including peptide and proteinstructure and function [1][2][3][4][5][6][7][8][9][10][11][12], enzyme activities [13][14][15][16][17], oligonucleotide functions [18][19][20], and ion-channel activities [21][22][23]. A quantitative analysis of
Beilstein J. Org. Chem.2006,2, No. 9, doi:10.1186/1860-5397-2-9
. [2][3][4][5][6][7][8][9] Such oligomers therefore have a particular appeal for extending understanding of proteinstructure and stabilization. However, much of this work has focused on simple cyclic β-amino acids and analogous studies of substituted derivatives are less well developed. One reason for
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Graphical Abstract
Scheme 1:
The furan-nitroacylate approach to poly hydroxylated ACHC derivatives