Sordarin, an antifungal agent with a unique mode of action

• Huan Liang

Beilstein J. Org. Chem. 2008, 4, No. 31, doi:10.3762/bjoc.4.31

• Huan Liang Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada 10.3762/bjoc.4.31 Abstract The sordarin family of compounds, characterized by a unique tetracyclic diterpene core including a norbornene system, inhibits protein synthesis in

• total syntheses (by the Kato, Mander and Narasaka groups), modifications of the glycosyl unit, and changes to the diterpene core (Cuevas and Ciufolini models) will also be discussed in this review. Keywords: antifungal; bioactivity; sordaricin; sordarin; total synthesis; Introduction For

• sordarin [17] in 2004 and 2006, respectively. Both Kato’s and Mander’s syntheses employed intramolecular Diels-Alder cyclizations to construct the norbornene-like framework, while an intramolecular Pd catalyzed Tsuji-Trost reaction was utilized by the Narasaka group to build the diterpene core. Kato’s