Phaeochromycins F–H, three new polyketide metabolites from Streptomyces sp. DSS-18

• Jian Li,
• Chun-Hua Lu,
• Bao-Bing Zhao,
• Zhong-Hui Zheng and
• Yue-Mao Shen

Beilstein J. Org. Chem. 2008, 4, No. 46, doi:10.3762/bjoc.4.46

• , Xiamen University, Xiamen, Fujian 361005, P. R. China School of Life Sciences, Xiamen University, No. 422 South Siming Road, Xiamen, Fujian 361005, China (address for correspondence); Phone: 86-592-2181722, Fax: 86-592-2181722 10.3762/bjoc.4.46 Abstract Three new polyketides, phaeochromycins F (1), G (2

• ), H (3), were obtained from the culture broth of marine actinomycete strain Streptomyces sp. DSS-18. Their structures were established on the basis of detailed spectroscopic analyses, including 1D-, 2D-NMR and HR-ESI MS techniques. Keywords: biological properties; isolation; polyketides; Streptomyces

• from marine derived actinomycetes, a strain of the genus Streptomyces was isolated from deep sediment collected from the west Pacific. Herein, we report the isolation and structure determination and biological properties of three new polyketides, namely phaeochromycins F (1), G (2) and H (3), from