Synthesis of (macro)heterocycles by consecutive/repetitive isocyanide-based multicomponent reactions

• Angélica de Fátima S. Barreto and
• Carlos Kleber Z. Andrade

Beilstein J. Org. Chem. 2019, 15, 906–930, doi:10.3762/bjoc.15.88

• macroheterocycles in a reduced number of steps. Keywords: consecutive/repetitive multicomponent reactions; isocyanide; isocyanide-based multicomponent reactions; (macro)heterocycles; Passerini reaction; Ugi reaction; Introduction Isocyanide (isonitrile) chemistry was first described by Lieke in 1859 [1] and forms

• very efficient in the fast obtention of (macro)heterocycles, and the number of examples from the literature has been increasing. Review Multicomponent reactions (MCRs) Multicomponent reactions are reactions in which three or more compounds are reacted yielding a product that retains most of the atoms

• IMCRs known and has found many applications in synthetic organic chemistry [2][3][9][10]. Among the IMCRs the Ugi reaction has been the most used in the repetitive/consecutive strategy for the synthesis of (macro)heterocycles. The union of different types of MCRs for the synthesis of more complex