Beilstein J. Org. Chem.2007,3, No. 31, doi:10.1186/1860-5397-3-31
heterocyclic systems, examples of their participation in the cycloaddition reactions are rare. In continuation of our interest on ketene acetals [5][6][7] we considered that 1,3-dipolarcycloaddition of the anion generated from the von Leusen's reagent (p-tolylsulfonyl)methyl isocyanide (TosMIC) 2 to AKDTAs 1
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Graphical Abstract
Scheme 1:
Cycloaddition of TosMIC to AKDTAs provide 2,3,4-trisubstituted pyrroles 3 and imidazole 4.