Design, synthesis and biological evaluation of 2,5-diaryloxazolo[4,5-d]pyrimidin-7-ylamines as selective cytotoxic agents against HeLa cells

• Maryna V. Kachaeva,
• Agnieszka B. Olejniczak,
• Marta Denel-Bobrowska,
• Victor V. Zhirnov,
• Yevheniia S. Velihina,
• Stepan G. Pilyo and
• Volodymyr S. Brovarets

Beilstein J. Org. Chem. 2026, 22, 390–398, doi:10.3762/bjoc.22.27

• Analytique, Université d’Orléans, Pôle de chimierue de Chartres, BP 6759, 45067 Orléans Cedex 2, France 10.3762/bjoc.22.27 Abstract Nine novel functionalized 2,5-diaryloxazolo[4,5-d]pyrimidin-7-ylamines were designed, synthesized and characterized using 1H, 13C NMR, IR spectroscopy, elemental analysis, and

• , 7, and 9 were selective against the tested lines. Compound 9 can be classified as the most attractive and promising candidate for further development against cervical adenocarcinoma. Keywords: ADMET analysis; anticancer activity; 2,5-diaryloxazolo[4,5-d]pyrimidin-7-ylamines; Introduction Purine

• [4,5-d]pyrimidin-7-amine derivatives 1–9. Synthesis of new 2,5-diaryloxazolo[4,5-d]pyrimidin-7-ylamines 1–9. Results of in vitro anticancer screening of the compounds 1 9. Complex pharmacokinetic profile of compounds 1, 7, and 9 predicted by ADMETlab3.0. The parameters of physicochemical properties of