Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing

• Luke O. Jones,
• Leah Williams,
• Tasmin Boam,
• Martin Kalmet,
• Chidubem Oguike and
• Fiona L. Hatton

Beilstein J. Org. Chem. 2021, 17, 2553–2569, doi:10.3762/bjoc.17.171

• solvent below freezing temperature. Due to their inherent interconnected macroporosity, ease of preparation, and biocompatibility, they are increasingly being investigated for use in biomedical applications such as 3D-bioprinting, drug delivery, wound healing, and as injectable therapeutics. This review

• implantation without surgical incision, and use as highly effective wound dressings. Furthermore, conclusions and outlooks are discussed for the use of these promising and durable macroporous cryogels. Keywords: 3D-bioprinting; cryogels; drug delivery; injectable cryogel; macroporous hydrogel; wound healing

• , drug delivery and wound healing applications. It should be noted that whilst this section contains reference to tissue engineering, expansive detail on the subject matter is beyond the scope of this review. 5.1. 3D-Bioprinting of cryogels 3D-printing of biomaterials, or bioprinting, enables the control