Beilstein J. Org. Chem.2013,9, 2615–2619, doi:10.3762/bjoc.9.295
of hexafluorothioacetone dimer (2,2,4,4-tetrakis(trifluoromethyl)-1,3-dithiethane, 1) with vinylamides leads to the rapid formation of [2 + 2] cycloadducts: 4-amino-2,2-bis(trifluoromethyl)thietanes. The reaction proceeds in polar solvents (DMF, DMSO) in the absence of a catalyst at elevated
was confirmed by single crystal X-ray diffraction.
Keywords: 1-(hexafluoroisopropyl)-3-vinyl-1,3-dihydro-2H-imidazole-2-thione; 2,2,4,4-terakis(trifluoromethyl)-1,3-dithiethane; 4-amino-2,2-bis(trifluoromethyl)thietanes; organo-fluorine; Introduction
Hexafluorothioacetone (HFTA) and