Beilstein J. Org. Chem.2020,16, 1411–1417, doi:10.3762/bjoc.16.117
-opening reaction of 4-fluoroisoxazoles and exhibited highly fluorescent luminescence and aggregation-induced emission (AIE), showing promise as a new fluorophore.
Keywords: aggregation-induced emission; boron ketoiminates; fluorescent probe; α-fluorinated boron ketoiminates; 4-fluoroisoxazoles
fluorescent luminescence characteristics of 4-fluoroisoxazoles, the synthesis of α-fluorinated boron ketoiminates (F-BKIs), and their photochemical properties.
Results and Discussion
Synthesis and optical properties of 4-fluorinated isoxazoles
Although there is a large number of fluorescent molecules
, fluorescent probes having an isoxazole scaffold are rare and the limited examples that are available also contain other fluorophores such as styryl, anthranyl, or pyrenyl groups in the molecules. We recently reported the synthesis of 3,5-diaryl-4-fluoroisoxazoles 3 that were found to have planar structures
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Graphical Abstract
Scheme 1:
Selective fluorination of isoxazoles and one-pot synthesis of 4-fluoroisoxazoles.