Silica- bound benzoyl chloride mediated the solid- phase synthesis of 4H-3,1-benzoxazin- 4-ones

• Kurosh Rad-Moghadam and
• Somayeh Rouhi

Beilstein J. Org. Chem. 2009, 5, No. 13, doi:10.3762/bjoc.5.13

• -acylaminobenzoic acids. The silica-grafted reagent (SBBC) was simply recovered after reaction and reused several times. Keywords: 4H-3,1-benzoxazin-4-one; silica-bound benzoyl chloride; solid-phase synthesis; Introduction Solid-phase approaches are gaining more and more applications in organic synthesis mainly

• features, a number of approaches have been developed for the synthesis of 4H-3,1-benzoxazin-4-ones. A literature survey regarding the synthesis of 2-substituted 4H-3,1-benzoxazin-4-one derivatives disclosed a variety of methods, including cyclodehydration of N-acylanthranilic acids by acetic anhydride [20