Beilstein J. Org. Chem.2011,7, 678–698, doi:10.3762/bjoc.7.80
summarizes the results of a long-term investigation of 5-alkoxymethyluracil analogues and is aimed, in particular, at methods of syntheses. Most of the presented compounds were synthesized in order to evaluate their biological activity, therefore, a brief survey of biological activity, especially antiviral
, cytotoxic and antibacterial, is also reported.
Keywords: 5-alkoxymethyluracil; biological activity; nucleosides; Review
Introduction
Modifications of nucleic acid components play a significant role in the field of nucleic acids research. In particular, nucleoside analogues find broad therapeutic