Synthesis of new fluorescent molecules having an aggregation-induced emission property derived from 4-fluoroisoxazoles

• Kazuyuki Sato,
• Akira Kawasaki,
• Yukiko Karuo,
• Atsushi Tarui,
• Kentaro Kawai and
• Masaaki Omote

Beilstein J. Org. Chem. 2020, 16, 1411–1417, doi:10.3762/bjoc.16.117

• light ray and the structures often include fluorescein, rhodamine, or 7-amino-4-methylcoumarin (7-AMC) scaffolds as fluorophores. These fluorophores usually exhibit strong fluorescence in dilute solutions, but most of their emissions are partially or completely quenched in the solid state or in highly

Skeletocutins M–Q: biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa

• Tian Cheng,
• Clara Chepkirui,
• Cony Decock,
• Josphat C. Matasyoh and
• Marc Stadler

Beilstein J. Org. Chem. 2019, 15, 2782–2789, doi:10.3762/bjoc.15.270

• cold 0.2 M glycine buffer at pH 10.5 was added. The amount of hydrolyzed 7-amino-4-methylcoumarin (AMC) was measured in a Tecan Infinite M200 PRO fluorescence spectrophotometer (excitation and emission at λ = 365 and 440 nm, respectively). Bestatin [12] and DMSO were used as positive and negative

A novel high-yield synthesis of aminoacyl p-nitroanilines and aminoacyl 7-amino-4-methylcoumarins: Important synthons for the synthesis of chromogenic/fluorogenic protease substrates

• Xinghua Wu,
• Yu Chen,
• Herve Aloysius and
• Longqin Hu

Beilstein J. Org. Chem. 2011, 7, 1030–1035, doi:10.3762/bjoc.7.117

• -nitroaniline (aminoacyl-pNA) and aminoacyl 7-amino-4-methylcoumarin (aminoacyl-AMC) are important synthons for the synthesis of chromogenic/fluorogenic protease substrates. A new efficient method was developed to synthesize aminoacyl-pNA and aminoacyl-AMC derivatives in excellent yields starting from either

• racemization, it does not result in satisfactory yields. Because of these limitations of the existing methods, there is still a need to develop a generally applicable method for the synthesis of aminoacyl-pNAs. Conjugation of Nα-protected amino acids with fluorogenic 7-amino-4-methylcoumarin (AMC) is similarly

• electron-withdrawing group [18][19][20]. We postulated that the selenocarboxylate/azide amidation could be a good solution to the problem of synthesizing aminoacyl-pNAs and aminoacyl-AMCs. Instead of p-nitroaniline and 7-amino-4-methylcoumarin, p-nitrophenyl azide and 7-azido-4-methylcoumarin would be used