Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale

• Janne Weisell,
• Jouko Vepsäläinen and
• Petri A. Turhanen

Beilstein J. Org. Chem. 2015, 11, 2189–2193, doi:10.3762/bjoc.11.237

• any NMR characterization data, only HPLC and MS data were presented, and these are rather unsatisfactory methods with which to prove the purity of a product. They also stated that there was 5–10% ADP (adenosine diphosphate) as an impurity in some preparations and that it is possible that there may

• Vantourout et al. [6]; however, we provide full details of the approach (method B, Scheme 1). In method A, the bis(tetrabutylammonium) salt of ADP was first treated with in situ prepared 3-methylbut-3-en-1-yl (trimethylsilyl) phosphorochloridate (2) (see synthesis route in Scheme 2) followed by deprotection

• ) salt is highly stable against chemical hydrolysis at room temperature. Since Vantourout et al. [6] did not report the amount of tetrabutylammonium used in their synthesis of ApppI, we tested whether mono tetrabutylammonium salts of ADP and ATP could be used as starting materials to produce ApppI (1

The facile construction of the phthalazin-1(2H)-one scaffold via copper-mediated C–H(sp²)/C–H(sp) coupling under mild conditions

• Wei Zhu,
• Bao Wang,
• Shengbin Zhou and
• Hong Liu

Beilstein J. Org. Chem. 2015, 11, 1624–1631, doi:10.3762/bjoc.11.177

• both seasonal allergic rhinitis (SAR) and nonallergic vasomotor rhinitis (VMR) [7]. As the lead of a series of poly ADP ribose polymerase (PARP) inhibitors, olaparib has been approved by the FDA as a potential treatment for germline BRCA mutated (gBRCAm) advanced ovarian cancer [8]; another PARP

Synthesis, characterization and DNA interaction studies of new triptycene derivatives

• Sourav Chakraborty,
• Snehasish Mondal,
• Rina Kumari,
• Sourav Bhowmick,
• Prolay Das and
• Neeladri Das

Beilstein J. Org. Chem. 2014, 10, 1290–1298, doi:10.3762/bjoc.10.130

• that selected triptycene derivatives show anticancer activities by virtue of inhibition of topoisomerase [29][30], obstruction of macromolecule synthesis [31], blocking of nucleoside transport [32], induction of caspase activities [33] and poly(ADP)-ribose polymerase-1 (PARP) cleavage [34], and at the

Methylidynetrisphosphonates: Promising C₁ building block for the design of phosphate mimetics

• Vadim D. Romanenko and
• Valery P. Kukhar

Beilstein J. Org. Chem. 2013, 9, 991–1001, doi:10.3762/bjoc.9.114

• halomethylidynetrisphosphonic acids 43 and 44 is shown in Scheme 23 [7]. The tris(tributylammonium) salt of methylidynetrisphosphonic acid was transformed into an ADP analogue 45 and into an analogue of ATP 46 using the method of Poulter and the phosphoromorpholidate procedure of Khorana and Moffatt, respectively. Diadenosine

Synthetic glycopeptides and glycoproteins with applications in biological research

• Ulrika Westerlind

Beilstein J. Org. Chem. 2012, 8, 804–818, doi:10.3762/bjoc.8.90

• cholerae, causes severe diarrhea and massive dehydration upon binding and entrance into the intestinal epithelial cells [119]. The AB5-type toxin consists of one toxic ADP-ribosyltransferase and five lectin subunits that bind to the gangloside GM1 ligands on the epithelial cell surface [120]. The cholera

Thermodynamic and kinetic stabilization of divanadate in the monovanadate/divanadate equilibrium using a Zn-cyclene derivative: Towards a simple ATP synthase model

• Hanno Sell,
• Anika Gehl,
• Frank D. Sönnichsen and
• Rainer Herges

Beilstein J. Org. Chem. 2012, 8, 81–89, doi:10.3762/bjoc.8.8

• Hanno Sell Anika Gehl Frank D. Sonnichsen Rainer Herges Otto-Diels Institut für Organische Chemie, Christian-Albrechts-Universität zu Kiel, Otto-Hahn-Platz 4, 24418 Kiel, Germany 10.3762/bjoc.8.8 Abstract For the condensation of anions such as phosphate and ADP to form ATP and water, nature

• ; Introduction Driving endergonic reactions with external energy sources is one of the challenging and so far unsolved problems in supramolecular chemistry. The best known example in nature is probably the condensation of phosphate and ADP to ATP, driven by a proton gradient across a membrane [1]. There are a

• of yeast pyrophosphatase, the phosphate group acting as the electrophile is activated by coordination to Mg2+ as well as by hydrogen bonding to a guanidinium group [12]. The electrophilicity of ADP in ATP synthase is even further increased by electron transfer to Mg2+ forming a radical ion pair [29

Coupled chemo(enzymatic) reactions in continuous flow

• Ruslan Yuryev,
• Simon Strompen and
• Andreas Liese

Beilstein J. Org. Chem. 2011, 7, 1449–1467, doi:10.3762/bjoc.7.169

• BC when the ancient Sumerians and Babylonians practiced the brewing of beer and winemaking [6]. Indeed, in vivo fermentation of sugars to ethanol by yeast is a complex process involving at least 12 enzymes and 2 cofactors, NAD+ and ADP. Nowadays microbial biotransformations have become an

Microwave assisted synthesis of triazoloquinazolinones and benzimidazoquinazolinones

• Aboul-Fetouh E. Mourad,
• Ashraf A. Aly,
• Hassan H. Farag and
• Eman A. Beshr

Beilstein J. Org. Chem. 2007, 3, No. 11, doi:10.1186/1860-5397-3-11

• ] anticancer, [5] anti-inflammatory, [6] anticonvulsant, [7] and antiproliferative activities as well as inhibitory effects for thymidylate synthase and poly-(ADP-ribose) polymerase (PARP). [8] An interesting method for quinazoline synthesis involved [5+1] annulation during the reaction of β-dicarbonyl