Beilstein J. Org. Chem.2021,17, 2194–2202, doi:10.3762/bjoc.17.141
nomimicin, hereafter named nomimicin A, were isolated from the culture extract of Actinomadura sp. AKA43 collected from floating particles in the deep-sea water of Sagami Bay, Japan. The structures of nomimicins B, C, and D were elucidated through the interpretation of NMR and MS analytical data, and the
cytotoxicity against P388 murine leukemia cells with IC50 values of 33 and 89 μM, respectively.
Keywords: Actinomadura; nomimicin; polyketide; spirotetronate; Introduction
Actinomycetes are a valuable source of bioactive compounds, accounting for approximately two thirds of all known antibiotics, and more
actinomycete of the genus Actinomadura. We herein describe the isolation, structure determination, and biological activities of 1‒3.
Results and Discussion
The producing strain Actinomadura sp. AKA43 was isolated from DSW collected at a depth of −800 m in Sagami Bay, Japan. Strain AKA43 was cultured in A16
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Graphical Abstract
Figure 1:
Structures of nomimicins A–D (4 and 1–3).
Beilstein J. Org. Chem.2020,16, 1100–1110, doi:10.3762/bjoc.16.97
actinomycetes” refers to non-Streptomyces actinomycetes [12] and the representative genera, such as Micromonospora, Actinomadura, Nocardia, Actinoplanes, and Saccharothrix, which are no longer rare in terms of difficulties in isolation, already provided thousands of new metabolites [13][14]. Meanwhile, the
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Graphical Abstract
Figure 1:
Structures of pseudosporamide (1) and pseudosporamicins A–C (2–4).