Beilstein J. Org. Chem.2021,17, 2939–2949, doi:10.3762/bjoc.17.203
.17.203 Abstract A genome mining survey combined with metabolome analysis of publicly available strains identified Couchioplanes sp. RD010705, a strain belonging to an underexplored genus of rare actinomycetes, as a producer of new metabolites. HPLC-DAD-guided fractionation of its fermentation extracts
were weakly inhibitory against Kocuria rhizophila at MIC 100 μg/mL and none were cytotoxic against P388 at the same concentration.
Keywords: Couchioplanes; prenylated tryptophan; rare actinomycete; unsaturated fatty acid; Introduction
Actinomycetes, a subgroup of filamentous Gram-positive bacteria
same approach to the different family (Pseudonocardiaceae) yielded mycetoindole, a new class of dehydrotryptophan derivative from Actinomycetospora [22].
As part of our continuing studies on the metabolites from underexplored rare actinomycetes, the genus Couchioplanes, another minor genus in