Antibacterial scalarane from Doriprismatica stellata nudibranchs (Gastropoda, Nudibranchia), egg ribbons, and their dietary sponge Spongia cf. agaricina (Demospongiae, Dictyoceratida)

• Cora Hertzer,
• Stefan Kehraus,
• Nils Böhringer,
• Fontje Kaligis,
• Robert Bara,
• Dirk Erpenbeck,
• Gert Wörheide,
• Till F. Schäberle,
• Heike Wägele and
• Gabriele M. König

Beilstein J. Org. Chem. 2020, 16, 1596–1605, doi:10.3762/bjoc.16.132

• bacteria Arthrobacter crystallopoietes (DSM 20117) and Bacillus megaterium (DSM 32). Keywords: antibacterial; Dictyoceratida; Nudibranchia; scalarane; sesterterpene; Introduction In habitats with intense competition and feeding pressure, such as coral reefs, sessile or slow-moving organisms commonly

• of this compound. In general, scalarane sesterterpenes are bioactive metabolites, mainly isolated from marine sources, such as Dictyoceratida sponges and the nudibranchs that feed on them [7][25][29][33][56]. So far, only six scalaranes containing cyclopropane rings, constructed of C-4, C-19 and C-20

• -methylenedeoxoscalarin within Spongia cf. agaricina, (Spongiidae, Dictyoceratida). Primordially, chromodorid nudibranchs feed upon a broad range of sponges, however, more derived genera like Glossodoris and Doriprismatica have taken to feeding upon a narrow range of sponges [23][27][47]. As the first chemical