Synthesis and acaricidal activity against Varroa destructor of α- and γ-costic acid dimers

• Alessandro Santarsiere,
• Ernesto Santoro,
• Maria Letizia Ciavatta,
• Marianna Carbone,
• Sonia Ganassi,
• Cosimo Tedino,
• Antonio De Cristofaro,
• Antonio Evidente and
• Stefano Superchi

Beilstein J. Org. Chem. 2026, 22, 1088–1096, doi:10.3762/bjoc.22.87

• and produced by different wild plant genera [1]. In particular, α-costic acid (1), also known as isocostic acid, (Figure 1) was first isolated from aerial parts of Dittrichia viscosa (syn. Inula viscosa) [2] and Dittrichia graveolens (L.) Greuter (syn. Inula graveolens) [3], herbaceous perennial

• ; HRESIMS (m/z): [M + Na]+ calcd for C32H46O4Na, 517.3294; found, 517.3298. Plant material, extraction, and purification of α-costic acid Whole aerial parts of Dittrichia viscosa plants were freshly collected in Algeria from naturally occurring populations. A voucher specimen was deposited at the herbarium

Use of costic acid, a natural extract from Dittrichia viscosa, for the control of Varroa destructor, a parasite of the European honey bee

• Kalliopi Sofou,
• Demosthenis Isaakidis,
• Apostolos Spyros,
• Anita Büttner,
• Athanassios Giannis and
• Haralambos E. Katerinopoulos

Beilstein J. Org. Chem. 2017, 13, 952–959, doi:10.3762/bjoc.13.96

• recent address: Department of Chemistry and Food Chemistry, TU Dresden, 01062, Dresden, Germany 10.3762/bjoc.13.96 Abstract Costic acid has been isolated from the plant Dittrichia viscosa and its efficacy against Varroa destructor, a parasite of Apis mellifera, the European honey bee, has been studied

• efficient agent for controlling varroosis in honey bee colonies. Keywords: Apis mellifera; Dittrichia viscosa; natural products; Varroa destructor; varroosis; Introduction The honey bee ectoparasite Varroa destructor (Anderson & Trueman) was discovered by Oudemans in 1904 [1]. The mite was located on the

• feeding place for bee colonies, and beekeeping has been a profitable practice of the local population since ancient years. Dittrichia viscosa (L.) W. Greuter (syn. Inula viscosa (L.) Aiton), an invading ruderal species of the Asteraceae family [29], is a herbaceous perennial plant which is widespread in