Beilstein J. Org. Chem.2019,15, 1786–1794, doi:10.3762/bjoc.15.172
successfully used to induce mechanochemical oxidative processes on several structurally different primary and secondary alcohols. The proposed redox process is safe, inexpensive and performing effectively, especially on the macroscale. Herein, an Ertalyte® jar has been successfully used, for the first time, in
a mechanochemical process.
Keywords: AZADO; Ertalyte®; green chemistry; mechanochemistry; NaOCl·5H2O; selective oxidation; TEMPO; Introduction
The conversion of primary and secondary alcohols to the corresponding carbonyl compounds (aldehydes and ketones, respectively) is of such importance in
with the unprecedented utilization of Ertalyte® jars, the mechanical activation allows obtaining the oxidized products from a broad spectrum of initial substrates. We show that the proposed mechanochemical method is definitely safe, performing effectively and inexpensive, thus providing an interesting
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Graphical Abstract
Scheme 1:
Oxidation of 3-pheny-1-propanol (1a) with N-chlorosuccinimide (NCS) in the presence of (2,2,6,6-tet...