Beilstein J. Org. Chem.2022,18, 722–731, doi:10.3762/bjoc.18.72
metabolic functions. Here, we describe a new UbiA-like prenyltransferase (Ptase) Ubi-297 encoded in a conserved operon of several bacterial taxa, including marine Flavobacteria and the genus Sacchromonospora. In silico analysis of Ubi-297 homologs indicated that members of this Ptase group are composed of
farnesylation of quinoline derivatives, such as 8-hydroxyquinoline-2-carboxylic acid (8-HQA) and quinaldic acid. The results of this study provide new insights into the abundance and diversity of Ptases in marine Flavobacteria and beyond.
Keywords: Flavobacteria; prenylation; Saccharomonospora; UbiA-like
biosynthetic repertoire of marine bacteria [14][15], the diversity of the encoded and yet often unexplored bacterial Ptases of Flavobacteria and Saccharomonospora strains sparked our interest. In this study we investigated three yet poorly described homologous Ptases within the UbiA superfamily and evaluated
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Graphical Abstract
Figure 1:
Prenylated aromatic metabolites are involved in cellular processes like cell respiration (coenzyme Q...
Beilstein J. Org. Chem.2014,10, 1796–1801, doi:10.3762/bjoc.10.188
their biosynthesis is unknown [10].
TDA exhibits a strong antibiotic activity against a broad spectrum of bacteria including alpha- and gammaproteobacteria, flavobacteria and actinobacteria [11], but not against the eukaryotic model organisms Artemia sp. and Caenorhabditis elegans, suggesting P
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Graphical Abstract
Figure 1:
TDA and related natural products from Phaeobacter inhibens.