Beilstein J. Org. Chem.2008,4, No. 26, doi:10.3762/bjoc.4.26
with benzyl azide or 2-morpholinoethyl azide in the presence of catalytic CuSO4 and sodium ascorbate to afford the triazoles 9 and 10, respectively, in good yield (Figure 5). The copper-catalyzed Huisgencycloaddition of terminal alkynes and alkyl azides favors formation of the 1,4-triazole
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Graphical Abstract
Figure 1:
The two general synthetic approaches to oxazolo[5,4-d]pyrimidines.